Standards, Guidelines and Extended Protocols

One of the longstanding ISCEV goals is to establish worldwide standard clinical protocols for electrophysiological examinations. Based on input from many members, ISCEV has published the following compilations of protocols. Thankfully, Springer has made these public access; since access on their site occasionally is not working right we here also provide local copies.

Current ISCEV Standards

mfERG  (= multifocal ERG)

Hoffmann MB, Bach M, Kondo M, Li S, Walker S, Holopigian K, Viswanathan S, Robson AG (2021) ISCEV standard for clinical multifocal electroretinography (mfERG) (2021 update). Doc Ophthalmol 142:5–16. PDF

Translated by the Chinese Visual Physiology Society in Chinese Ophthalmology Society:
ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition) [Translated by Chinese Visual Physiology Society in Chinese Ophthalmology Society] Chinese Journal of Ophthalmology, December, 2020, 56(12):899-906. DOI

ERG

Robson AG, Frishman LJ, Grigg J, Hamilton R, Jeffrey BG, Kondo M, Li S, McCulloch DL (2022) ISCEV Standard for full-field clinical electroretinography (2022 update). Doc Ophthalmol 144(1):165–177.  PDF

2015-version translated by the Chinese Visual Physiology Society in Chinese Ophthalmology Society:
ISCEV Standard for full-field clinical electroretinography (2015 update). Chinese Journal of Ophthalmology, September, 2020, 56(9):662-669. DOI

EOG

Constable PA, Bach M, Frishman L, Jeffrey BG, Robson AG (2017) ISCEV Standard for Clinical Electro-oculography (2017 update). Doc Ophthalmol 134(1):1–9.  PDF

[Erratum (switch to open access, correction of one axis label in a figure):
Constable PA, Bach M, Frishman LJ, Jeffrey BG, Robson AG; International Society for Clinical Electrophysiology of Vision (2017) Erratum to: ISCEV Standard for clinical electro-oculography (2017 update). Doc Ophthalmol 134(2):155

PERG  (= Pattern ERG)

Bach M, Brigell MG, Hawlina M, Holder GE, Johnson MA, McCulloch DL, Meigen T, Viswanathan S (2013) ISCEV standard for clinical pattern electroretinography (PERG) – 2012 update. Doc Ophthalmol 126:1–7.  PDF

VEP

Odom JV, Bach M, Brigell M, Holder GE, McCulloch DLL, Mizota A, Tormene AP (2016) ISCEV standard for clinical visual evoked potentials – (2016 update). Doc Ophthalmol 133(1):1–9

VEP Standard, free from Springer [and since, due to some glitch, it's not free, here the PDF]

Translated by Chinese Visual Physiology Society in Chinese Ophthalmology Society:
ISCEV standard for clinical visual evoked potentials: (2016 update). Chinese Journal of Ophthalmology, August, 2020, 56(8): 587–592. DOI

Calibration and Recording

Brigell M, Bach M, Barber C, Moskowitz A, Robson J (2003) Guidelines for calibration of stimulus and recording parameters used in clinical electrophysiology of vision. Doc Ophthalmol 107:185–193  

Calibration Guidelines, free from Springer [and since, due to some glitch, it's not free, here the PDF]

→Draft of the 2022 update. Please send your feedback to the chair of the committee (daphne.mcculloch@uwaterloo.ca) and ISCEV Director of standards (anthony.robson3@nhs.net) before 2021-11-24.

ISCEV guide to visual electrodiagnostic procedures (2018)

Robson AG, Nilsson J, Li S, Jalali S, Fulton AB, Tormene AP, Holder GE, Brodie SE (2018) ISCEV guide to visual electrodiagnostic procedures. Doc Ophthalmol 136:1–26.  PDF

Translated by Chinese Visual Physiology Society in Chinese Ophthalmology Society:
ISCEV guide to visual electrodiagnostic procedures. Chinese Journal of Ophthalmology, July, 2020, 56(7): 492–508.  DOI

Extended Protocols

ISCEV approves Extended Protocols that specify rigorous procedures for applications such as non-standard diagnostic testing and clinical trials. Process for Proposal, Review and Approval of Extended Protocols 2009 [PDF].

All links will download the pertinent PDF.

Approved Protocols

• Hamilton R, Bach M, Heinrich SP, Hoffmann MB, Odom JV, McCulloch DL, Thompson DA (2021) ISCEV extended protocol for estimating visual acuity using VEP spatial frequency thresholds. Doc Ophthalmol 142:17–24
  
  
• Brigell M, Jeffrey BG, Mahroo OA, Tzekov R (2020) ISCEV extended protocol for derivation and analysis of the strong flash rod-isolated ERG a-wave. Doc Ophthalmol 140:5–12
  
  
• Perlman I, Kondo M, Chelva E, Robson AG, Holder GE (2020) ISCEV extended protocol for the S-cone ERG. Doc Ophthalmol 140:95–101
  
  
• Johnson MA, Jeffrey BG, Messias AMV, Robson AG (2019) ISCEV extended protocol for the stimulus–response series for the dark-adapted full-field ERG b-wave. Doc Ophthalmol 138:217–227
  
  
• McCulloch DL, Kondo M, Hamilton R, Lachapelle O, Messias AMV, Robson AG, Ueno S (2019) ISCEV extended protocol for the stimulus–response series for light-adapted full-field ERG. Doc Ophthalmol138:205–215
  
  
• Frishman L, Sustar M, Kremers J, McAnany JJ, Sarossy M, Tzekov R, Viswanathan S (2018) ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram. Doc Ophthalmol 136:207–211
  
  
• Thompson D, Fujinami K, Perlman I, Hamilton R, Robson AG (2018) ISCEV extended protocol for the dark-adapted red flash ERG. Doc Ophthalmol 136:191–197
  
  
• Sustar M, Holder GE, Kremers J, Barnes CS, Lei B, Khan NW, Robson AG (2018) ISCEV extended protocol for the photopic On–Off ERG. Doc Ophthalmol 136:199–206