Standards, Guidelines and Extended Protocols

One of the longstanding ISCEV goals is to establish worldwide standard clinical protocols for electrophysiological examinations. Based on input from many members, ISCEV has published the following compilations of protocols. Thankfully, Springer has made these public access; since access on their site is occasionally not working right we here also provide local copies.

Standards available for free only →here (scroll down to Society Guidelines/Standards).

Current ISCEV Standards

mfERG  (= multifocal ERG)

Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM (2012) ISCEV Standard for clinical multifocal electroretinography (2011 edition). Doc Ophthalmol 124:1–13 mfERG Standard (free from Springer)

ERG

McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130:1–12 

ERG Standard (free from Springer).

Erratum: Table 1 in the above publication gives an incorrect number as the lower bandpass for dark-adapted OPs. The correct value is “75 Hz”, as correctly stated on page 8, 2nd paragraph. Erratum PDF (free from Springer)

EOG

Constable PA, Bach M, Frishman L, Jeffrey BG, Robson AG (2017) ISCEV Standard for Clinical Electro-oculography (2017 update). Doc Ophthalmol 134(1):1–9

[Erratum (switch to open access, correction of one axis label in a figure): Constable PA, Bach M, Frishman LJ, Jeffrey BG, Robson AG; International Society for Clinical Electrophysiology of Vision (2017) Erratum to: ISCEV Standard for clinical electro-oculography (2017 update). Doc Ophthalmol 134(2):155]

PERG  (= Pattern ERG)

Bach M, Brigell MG, Hawlina M, Holder GE, Johnson MA, McCulloch DL, Meigen T, Viswanathan S (2013) ISCEV standard for clinical pattern electroretinography (PERG) – 2012 update. Doc Ophthalmol 126:1–7 [DOI]

PERG Standard (free from Springer)

VEP

Odom JV, Bach M, Brigell M, Holder GE, McCulloch DLL, Mizota A, Tormene AP (2016) ISCEV standard for clinical visual evoked potentials – (2016 update). Doc Ophthalmol 133(1):1–9VEP Standard (from Springer) [and since, due to some glitch, it's not free, here the PDF]

Calibration and Recording

Brigell M, Bach M, Barber C, Moskowitz A, Robson J (2003) Guidelines for calibration of stimulus and recording parameters used in clinical electrophysiology of vision. Doc Ophthalmol 107:185–193  

Calibration Guidelines (free from Springer) [and since, due to some glitch, it's not free, here the PDF]

Calibration Guidelines, 2020 edition (draft PDF)

ISCEV guide to visual electrodiagnostic procedures (2018)

Robson AG, Nilsson J, Li S, Jalali S, Fulton AB, Tormene AP, Holder GE, Brodie SE (2018) ISCEV guide to visual electrodiagnostic procedures. Doc Ophthalmol 136:1–26. 
doi: 10.1007/s10633-017-9621-y   [PDF]

Extended Protocols

ISCEV approves Extended Protocols that specify rigorous procedures for applications such as non-standard diagnostic testing and clinical trials. Process for Proposal, Review and Approval of Extended Protocols 2009 [PDF].

All links will download the pertinent PDF.

Approved Protocols

• McCulloch et al. (2019) ISCEV extended protocol for the stimulus–response series for light-adapted full-field ERG
  
  
• Frishman et al. (2018) ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram
  
  
• Thompson et al (2018) ISCEV extended protocol for the dark-adapted red flash ERG
  
  
• Sustar et al. (2018) ISCEV extended protocol for the photopic On–Off ERG

CURRENT DRAFTS with REQUEST4COMMENTS

• ISCEV extended protocol for derivation and analysis of the strong flash rod-isolated ERG a-wave.
  Please email feedback to Mitch Brigell (corresponding author) and Anthony Robson (Director of ISCEV Standards)
  
  
• ISCEV extended protocol for the S-cone ERG.
  Please email feedback to Ido Perlman (corresponding author) and Anthony Robson (Director of ISCEV Standards).
  
  
• ISCEV guidelines for measurement and calibration of stimulus and recording parameters used in clinical electrophysiology of vision, 2020 edition.
  Please email feedback to Michael Bach (corresponding author) and Anthony Robson (Director of ISCEV Standards)
  
  
• ISCEV extended protocol for estimating visual acuity using VEP spatial frequency thresholds.
  Please email feedback to Ruth Hamilton (corresponding author) and Anthony Robson (Director of ISCEV Standards)

Please email any feedback to Anthony Robson (Director of ISCEV Standards, anthony.robson3@nhs.net)