With an introduction by past-past-past president Eberhart Zrenner.
Videos assembled/edited by Richard Smith, thank you!
ISCEV and the Scientific Community at Large Mourn the Loss of Dr Samuel G. Jacobson
Samuel G. Jacobson, MD, PhD, William C. Frayer Professor of Ophthalmology, served as director of the Center for Hereditary Retinal Degenerations, which he established at Scheie Eye Institute in 1995. Dr. Jacobson, in his 40+ year career in science and medicine, distinguished himself as a caring and compassionate physician, and a world-class scientist. He entered the field of inherited retinal diseases when clinical specialists were rare, there was little medical or scientific interest in genetic blindness, and there were no treatments. Over decades, he advanced understanding of the molecular mechanisms of these disorders. He was a pioneer in the application of gene-based and mechanism-driven therapies for diseases previously considered as incurable. During his tenure, he trained many clinicians currently working in the field of retinal degenerations, and he has been the recipient of major awards in visual science. He is survived by his wife, Jean, daughter, Maxine, and brother, Fruman (Marian). Funeral services will be private. The family requests in lieu of flowers, donations be sent to the Eugenia R. Jacobson and Max M. Jacobson, M.D. Memorial Fund at the University of Illinois Foundation (visit give.uic.edu – Fund Number 12772236), or to the charity of your choice.
Professor Yutaka Tazawa, Professor Emeritus in the Department of Ophthalmology at Iwate Medical University in Japan passed away on 8 June 2022. First, I would like to pay tribute to Professor Tazawa on behalf of ISCEV members.
He was born in 1937 in Morioka in Iwate prefecture and grew up there. After graduating from Iwate Medical University, he started his residency and postgraduate work under supervision of Professor Kitetsu Imaizumi who was a pioneer of corneal transplantation in Japan. Professor Imaizumi’s work led to subsequent studies to examine the possibility of whole eye transplantations. As a result, Professor Tazawa’s early work with Professor Imaizumi led to his participation in helping to develop a new system capable of sustaining eyes long after removal; this made it possible for eyes to be used in transplantations performed at later time. To accomplish this work, he temporarily relocated to the University of Oregon Medical School and worked with Professor Seaman, a hematologist. During this time, he successfully developed his own system to record ERGs from isolated and perfused bovine eyes, the results of which were first published in 1972 in Investigative Ophthalmology and Visual Science. He continued to research perfused bovine eyes using his own system, and in conjunction with his research fellows, he was able to determine how hypoxia and hypothermia affected the ERG. Because of his great achievements, he was promoted to a professor and chairman of Ophthalmology at Iwate Medical University in 1975 when he was as young as 38 years of age. After that he dedicated himself to clinical research of electrophysiology. With his co-workers, he studied the ERG c-wave in patients with retinal diseases, with many new findings. His interest in the mfERG led to the detection of a new wavelet; the “s-wave”, originating from retinal ganglion cells. Professor Tazawa and his co-workers actively researched the s-wave and elucidated its usefulness in functional analyses of glaucoma and optic nerve diseases.
He has been a member of ISCEV since 1974 and has many friends in this society. He served as a board member from 1978 to 1982, starting in 1983 as Vice President for the next 8 years. His most important contribution was his work on organizing the 16th ISCEV Symposium, of which he also served as the President, which took place in Morioka in 1978. Other leadership roles have included serving as the president of Japanese Society of Clinical Electrophysiology of Vision (JSCEV) for a long time.
Because of his distinguished contribution to electrophysiology of vision, he was honored with the prestigious Emiko Adachi’s Award and gave us a lecture at the 51st ISCEV in 2013 entitled “From memories of my research life in my young days”, shared his experiences from his research on perfused bovine eyes, and provided interesting details on how he overcame many difficulties by utilizing novel ideas and his passion for the research.
He was not only a great scientist but also a great clinician and mentor in ophthalmology. Because of his distinguished contribution to ophthalmology in Asia, The Asia-Pacific Academy of Ophthalmology gave him a medal of The Distinguished Service Award of APAO in 2010.
Since Professor Tazawa had been admired and respected by colleagues, co-workers and disciples, more than 300 people got together in his farewell party to congratulate his retirement and 30-year dedication as a professor in 2005. We would like to thank him for his tremendous and long-standing contributions to the clinical electrophysiology of vision.
Shigeki Machida, MD, PhD
Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center
In memoriam – Professor Hisako Ikeda-Wolstencroft, 1928–2021
Earlier this year, the family of Professor Hisako Ikeda-Wolstencroft, Emeritus Professor of University of London and long term Head of Vision Research Unit of Rayne Institute, St. Thomas Hospital, London, notified us that she quietly passed away on 22 December 2021 among her dear family and friends, aged 93. Professor Ikeda was born on 31 July 1928 in Osaka, Japan. Daughter of Kiguma and Chizu (Adachi) Okamula. She studied at Tokyo Bunrika University where she achieved Master of Arts in 1955. She than moved to UK and achieved the title of Doctor of Philosophy at London University in 1960 and the title of Doctor of Science at London University in 1980. She was Head of vision research unit, Rayne Institute, London, since 1974 and professor of visual physiology, St. Thomas Hospital Medical School, London, since 1982. She retired in 1993 and became Emeritus Professor of visual physiology United Medical and Dental Schools Guy's and St. Thomas' Hospital London, United Kingdom.
In 1979, Ikeda-Wolstencroft was awarded the Eldridge Green Lectureship from the Royal Society of Medicine, London, UK, for her outstanding contributions to ophthalmology. Ikeda-Wolstencroft co-authored several books on visual pathways and neurobiology, including ‘Development of Visual Pathways in Mammals’ (1983), ‘Textbook of Clinical Neurophysiology’ (1987) and ‘Neurobiology of the Inner Retina’ (1988). Alongside these works, is her extensive contribution to research, having published over 200 articles in scientific journals, as well as being a member on the Editorial Board for the journal Vision Research.
Ikeda-Wolstencroft’s commitment to her research and the community is further demonstrated by her membership of numerous national and international societies. She was a member of ISCEV, Physiological Society, International Brain Research Organisation, European Neurosci. Association, ARVO, ISER, Multiple sclerosis Society, to name but a few.
Her research interests were focused on retinal neurotransmission and mechanisms of development of demyelination. Perhaps one of her most discussed theories was that amblyopia also originates in the retina, not only in brain. This has recently received renewed interest as it was found that tetrodotoxin injection in the eye, a drug that temporarily blocks firing of ganglion cells, can »reset« the blocked synapses and lead to cortical remodeling, improving vision in the amblyopic eye. Her rich scientific career has been documented in proceedings of her retirement symposium in 1993 with contribution of many established scientists of the time. The book is available at the following link: https://g.co/kgs/Fk4aX1.
Hisako Ikeda was a role model of many of us that had a privilege to be her PhD students, among others Samuel Jacobson, Jonathan Robbins, Mark Hankins and myself. Her approach, persistence and enthusiasm transpired through us with our scientific challenges and our students.
Professor Ikeda was most admirable scientist with creative personality that, for her time, established world class methodology in both, clinical and basic visual neurophysiology. She was ahead of her time in many ways and paved a way towards, what is now commonly called, translational science. She will be warmly remembered in hearts of many ISCEV members that knew and admired her.
Marko Hawlina, Professor of Ophthalmology, University of Ljubljana, Slovenia
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2021 – Results of our Mail Ballot Elections
With a high voting turnout (70%) you elected these three candidates as new members-at-large to the ISCEV Board:
Congratulations! And heartfelt thanks to those not elected this time for standing and being ready to work for ISCEV! To recall more details on the choices, you can find the "News Extra 2021" here.
In Memoriam – Peter Gouras (1930–2021)
It is with great sadness that we learned of the passing of world class vision scientist Peter Gouras on 8 January 2021 in Baden-Baden, Germany at the age of 90. Born 1930 in Brooklyn, New York, N.Y. he received his B.A. degree in Biology in 1951 and his MD degree in 1955 at Johns Hopkins University, Baltimore, Maryland. Peter joined the National Institutes of Health in 1959 and became chief of the Neurophysiology Section of the National Eye Institute in 1970. In 1978 he joined Columbia University in New York as Professor of Ophthalmology, where he continued working and publishing until 2019. He was married to Ute Keppler-Gouras; they raised two sons, Eckhart and Gunnar, and daughter Roswitha, all becoming highly successful professionals.
Peter’s passion for science was boundless, and his discoveries were innumerable. In 1958 he presented the first demonstration of optical changes (spreading depression) caused by neural activity; in 1960 he provided evidence that retinal horizontal cells are forming an electrical syncytium. For the next ten years a very fruitful era followed, together with John Armington and Ralf Gunkel, Ron Carr and Eliot Berson, resulting in a spectacular widespread recognition of the value of clinical application of electroretinography. Multiple discoveries ensued, pertaining to numerous retinal diseases published in top journals, including several articles in Science. From 1966 on, Peter focused on cellular electrophysiology, identifying the responses from parvo-, magno- and S-cone systems in primate retina, and describing rod and cone signals and the characteristics of processing chromatic information in the retinal circuitry, together with Günther Niemeyer, Helga Kolb, Ralph Nelson, Francisco de Monasterio, Ted Famiglietti, Eberhart Zrenner, David Tolhurst and Jürgen Krüger, among others, including work in isolated arterial perfused eyes and monkey striate cortex. In parallel he continued his clinical work, publishing a series of papers on electroretinography and electrooculography and their applications in hereditary and acquired retinal diseases. He discovered a unique form of retinal degeneration with supernormal rod responses and other progressive cone-rod degenerations – bridging findings with non-invasive electrophysiology, achieved together with coworkers Dan Finkelstein, Cynthia MacKay, Suichi Yamamoto, Masamoto Saeki, Daniel Salchow and Stephen Tsang. with cellular functions of neurons and retinal pigment epithelium, which he was studying in his lab in parallel, together with Mary Flood, Jim Haley, Hild Kjeldbye, Robert Lopez, Shonit Das and Bill Blaner.
Later in his career he focused on a new field, transplantation of cultured human retinal cells for development of remedies for progressive retinal degeneration. Further outstanding discoveries were made in studying the genetic and biochemical mechanisms of retinal degeneration, together with Stephen Tsang, Debora Farber, Stephen Goff, Rando Allikmets, Janet Sparrow, Jana Zernant, Antje Biesemeyer, Martha Neuringer, and many others over the years.
I admired Peter enormously, for his infectious enthusiasm, his perseverance in seeking to understand especially serendipitous findings during the long hours and night shifts when recording from primate retina, his ability never to be victim of circumstances, his dedication to stay on track once he had set his mind to a goal, even if he knew that he probably never might reach it but that he might make interesting discoveries on the way. He always was very open speaking about his ideas, discussing and sharing know-how, knowledge and experience, not minding that others might continue to work on such ideas. At the same time he could fiercely criticize weak research or fight hypotheses that to his opinion led into a wrong direction.
I enjoyed very much the friendliness of Peter’s family when I had the privilege of living in their house in Bethesda for one and a half years, meeting the family members and the small kids almost daily. I was invited every few weeks to family dinners with guests, mostly high-ranking scientists. After 1.5 years at NIH I also had the chance to join him at Columbia University for week-long visits, working in the laboratory, again staying in the wonderful Gouras House in Riverdale. I have collected unforgettable memories, speaking all day long about findings in the lab, discussing new publications and sketching out new experiments and developing hypotheses about observations we couldn’t understand initially.
Peter was always an original thinker, often swimming against the established stream of thoughts which not always made him friends. In many ways I always saw in him a sort of Christopher Columbus, who knew that there must be something important beyond the horizon. Like Columbus, Peter wanted to know what there is – and it was he who was assembling a crew to join him, who didn’t give up when there were storms, who encouraged his team to keep up their efforts, and who could read the little signs telling him that he was on the right path. Like Columbus, he might have arrived at places different from what he imagined when starting his journey, but he found instead places where new things were still to discover. Like Columbus, he easily left areas that he had charted already, coming back in a while, and he was on a lifelong journey of discovery until the last year of his life. He rather lived three lives, as physician caring for his patients, as neurophysiologist trying to understand the neural signals, and as cell biologist looking for structural and functional restoration.
We will miss him as a role model of a most dedicated original scientist, always full of joy, spreading his ideas and sharing his findings, and we will miss him as companion and friend. However, he will remain in our hearts and he will remain a legend in ophthalmological research.
Eberhart Zrenner, Department of Ophthalmology, University of Tübingen, Germany (former ISCEV President)
2020 – Results of our Mail Ballot Elections
To recall more details on the choices, you can find the "News Extra 2020" here.
ISCEV being a member society of the International Council of Ophthalmology, it is our pleasure to call out the virtual World Ophthalmology Congress.
2020-01-02 Results of our email ballot: President & 2022 Symposium
As detailed in this recent NewsExtra PDF, we had two eminent members serving as candidates for ISCEV President and two exciting offers for the 2022 ISCEV Symposium. The final vote was performed via email ballot; the results are very clear, and we would first like to thank those who were not elected this time for their dedicated efforts of giving us such great choices, helping to advance our society while keeping the “ISCEV family spirit” alive. The results were as follows:
ISCEV President beginning 2020: Dr. Ruth Hamilton
Symposium site 2022: Kyoto, Japan (organizer: Prof. Masayuki Horiguchi)
2019-10-10 Election Results during the Membership Meeting in Seoul
To succeed Patrizia Tormene as president beginning in 2020, a nomination committee chaired by Prof Colin Barber presented a slate of three candidates. For the International ISCEV Symposium in 2022 three gracious offers were communicated to our Secretary General. According to our Bye-Laws, the members present at the membership meeting select two of these possibilities each by secret vote. The outcome in Seoul (wonderful Symposium!) was as follows:
Presidential candidates: Ruth Hamilton (UK) and Shuichi Yamamoto (Japan).
The final decision will be performed by mail ballot soon, where all (paid) members can cast their vote.
2019 – Long-term ISCEV member Graham E. Holder selected “Visionary of the Quarter"
We proudly announce: Vision Research Europe has selected our long-term member Prof Graham E. Holder, formerly at Moorfields, now in Singapore, as “Visionary of the Quarter”.
His personal journey through the human visual system with clinical electrophysiology entitleld “From back to front and back again!” is available in full detail here.
2019 – ISCEV Board Member Laura Frishman receives the Esther Farfel Award, University of Houston's highest award
We are proud to announce that long-term ISCEV member Laura Frishman has received the prestigious Esther Farfel Award, the highest her university assigns. The award, a symbol of overall career excellence, carries a cash prize of $10,000.
Laura is a scientist with many outstanding contributions in our field. She is an ISCEV Board Member, was Editor of our Journal and currently serves as Vice President Americas. We feel that this award is most appropriate. You can find more details about her career here. We are very happy for you, Laura! (Image: University of Houston)
2018 – Honorary Member Michael Bach receives the prestigious “von Graefe Award”
The Von Graeve Award was created in memory of Albrecht von Graefe in place of the von Welzschen-Graefe-Preis by donations of the German teachers of ophthalmology as well as of the Association of Rhineland-Westphalian ophthalmologists. It serves to promote ophthalmology by honouring scientific achievements. The von Graefe prize is awarded every two years for outstanding scientific achievements in the field of ophthalmology in the German-speaking world. The awardee will present a von Graefe lecture at a ceremony following the annual meeting of the DOG in September 2019. The award procedure took place in the former “Bundestag” hall in Bonn at the yearly meeting of the German Ophthalmological Society. (Image: Biermann-Verlag)
Professor Graham Frederick Anthony Harding, DSc, PhD, BSc, Hon FRCP, FBPsS, CPsychol (1937–2018) graduated in Psychology from University College, London in 1961. He obtained a PhD in EEG and Psychiatry from Birmingham University and a DSc from the University of Aston. In 1998, he was awarded an Honorary Membership of the Royal College of Physicians for outstanding contributions to medicine. Graham established the Clinical Neurophysiology Unit at Aston University in 1963 and was head of that Unit until his retirement in 2002. His special areas of interest were the electrophysiology of vision and photosensitive epilepsy.
His scientific work was key to elucidating the neurophysiological mechanisms responsible for the photoparoxysmal EEG response and stands as an example of how laboratory research can lead to societal impact through the development of UK broadcasting guidelines which, in turn, paved the way for their adoption by many other countries worldwide.
He first studied Visual Evoked Potentials in photosensitive patients, but with links to the Birmingham Midland Eye Hospital, many studies followed characterising the value and application of evoked potentials to the study of visual disorders. These included the prediction of ocular surgical outcome, the study of optic atrophies, the effect of multiple sclerosis, and the application of VEP’s during orbital surgery. Latterly, seminal studies were to include flash and pattern VEP in Alzheimer’s Disease and characterizing the effects on vision of the anti-convulsant Vigabatrin.
With links to the Birmingham Children’s Hospital, Graham and colleagues studied the development of vision in babies, including the development of the ERG, flash and pattern VEP. The pattern VEP was found to be present from 32 weeks post-menstrual age, and they found that colour vison was not operative in young babies until six weeks of age. These studies included Grahams own son Anthony.
Perhaps Graham’s greatest legacy was that he inspired a generation of scientists. He graduated more than 40 PhD and MD students, and published more than 350 articles in the fields of electroencephalography (EEG), visual evoked potentials (VEP) and Magnetoencephalography (MEG).
He was a gentle and humorous man with a sharp intellect and generous spirit. He enthused his colleagues and students with a sense of the possible. He often quoted his mentor Grey Walter, ‘Keep your band pass filters open and trust your instincts’. This advice served him, and those who benefitted from his mentorship, well.
Paul Furlong (with edits by Michael Bach)
The death of Pr Jean-Claude Hache has saddened us all. In Lille, he created and developed a department of functional explorations of vision (first in France). His high skills in computing in a very early period allowed him to develop new systems of incremental analysis in visual electrophysiology. He has pursued ongoing research in the field of fundamental sciences, clinical applications and even invention of new visual exploration devices.
Not only was he “passionné et passionnant”, he had an immense culture and humanism that he shared with us without counting his time; he was also a visionary.
We will remember his accuracy. Nodding and smiling he showed us how to improve our practice. He was warm with everyone who desired to improve his knowledge. He chose oral transmission speaking eloquently every time he could with colleagues more than papers and was a charismatic ambassador to promote electrophysiology.
He gave all his time to the patients, to his department, to the students and the colleagues in France and abroad. He created in 1976 with a team of French speaking colleagues the SILFEV (Société internationale de langue française d’exploration de la vision) that became later the SEVE. He succeeded with the help of Françoise, his so devoted and charming wife. • Even in his latest days he would still find the time to send a comforting message.
With his departure, we have lost not only a charismatic mentor but also a warm friend. His presence will however remain with us all in our day to day practice and in our life as well.
Martine Chrochet & Pierre Lachapelle
In 1948 the Institute of Ophthalmology was opened under the guidance of Sir Stewart Duke Elder in Judd Street in London. Formal research into the science of Ophthalmology was born in the UK and a number of bright young research scientists were gathered under this one roof but with the benefit of close communication with the surrounding clinical eye departments in London. Geoffrey Arden came to the Institute as a PhD student at this time obtaining his PhD in photochemistry and then went on to complete a medical degree. Geoffrey had an exceptionally enquiring mind and an enormous knowledge even of matters far removed from Ophthalmology. He spent some time studying under Ragnar Granit in Stockholm and KT Brown in San Francisco. After returning from the United States he returned to the Institute in London to become what was colloquially known as an “elderberry”, that is to say one of Sir Stewart Duke Elder’s prodigies. His background knowledge of electronics and his research experience in Stockholm and San Francisco no doubt concentrated his interest in the electrical changes in the eye and building on the work of Jules Francois in Belgium he developed the Electro-oculogram as a clinical test. His research facility at the institute became the first clinical electrophysiological department in the UK and he was appointed Professor and honorary consultant at Moorfields Eye Hospital. Those attending ISCEV and other international meetings will remember his pioneering work on cortical evoked potentials and the pattern ERG and during informal evening discussions at the meetings he seemed just as at home discussing the wavelets of the ERG as Proust or Pepys diary. He will be remembered for his ability to put his finger on the answer to a research problem when all around were scratching their heads. His other research interest included the clinical testing of Achromatic and Colour Contrast Sensitivity, Diabetic Retinopathy and Macular Degeneration. Geoffrey was invited to give several named lectures both in the UK and abroad He was awarded the Doyne medal at the Oxford Ophthalmological congress in 1984 and the Mackenzie Medal in 1989. Even after retiring as Professor at the University of London he kept an active interest in his research and in an emeritus capacity he continued to collaborate with research workers in the US and Europe. He was appointed an honorary fellow of the Royal College of Ophthalmologists in 2008 and in 2010 an honorary research fellow at City University London. A recent paper published in Eye in 2010 developed the theory that impending Diabetic Retinopathy might be prevented by reducing the oxygen consumption of rods when asleep and preliminary results conformed this. The reduction in oxygen consumption was achieved by the subjects wearing an illuminated mask when asleep. In 2011 he delivered the Adachi Lecture at the Quebec meeting of ISCEV which turned out to be a tour de force, achieving a higher audience approval rating than any of the previous Adachi lectures. Geoffrey was an accomplished pianist and this was his favourite relaxation after a busy day. He died after a short illness on 19th March 2018 and leaves behind his wife Sheila whom he married in 1955 and his two children.
2016 – Honorary Member Eberhart Zrenner received the highly prestigeous “von Graefe Medal”
The German Ophthalmological Society (DOG) awarded the von Graefe Medal to our esteemed college, honorary member and former president Eberhart Zrenner. This award is only handed out every 10 years and the highest award by the DOG. It honours his lifelong achievements in ophthalmology and vision science. The award ceremony took place on 1 October 2016 in Berlin during the yearly DOG conference. Prof Helbig, president of the German Ophthalmological Society, called out the development of the retinal implant technology among Prof Zrenner's many achievements. In our society Prof Zrenner has been an ardent promotor for Standards, served as Secretary General and as President, and has received the Adachi Award. We are happy for him (and proud ourselves). A detailed account of his many accomplishments earning him this reward can be found at Pro Retina (in German).
In Memoriam – Isabelle Ingster-Moati (✝2015)
Dr. Mathieu Robert tells us:
It is with my deepest regrets that I inform you, on behalf of her family, of Isabelle Ingster-Moati's death on Saturday, 31 January. She was a close colleague and taught me all I know about electrophysiology. As you know, she was very much involved in her clinical activities at Necker hospital for sick children and her teaching at University Paris Diderot. She held the Diplôme d'Université “Explorations de la fonction visuelle”, through which she formed a new generation of electrophysiologists in France and on the continent.
She fought her disease with strength and dignity, most of her collaborators being unaware of it, and carried on working until the very end. She gave us a fantastic lesson of life and she will be regretted by all those who knew her. I know she was very attached to the ISCEV community and read CEVnet everyday.
The funeral will be held on Wednesday, 4 February at 3:30 p.m., Bagneux Cemetery, close to Paris.
Contact: Her son Charles Moati, firstname.lastname@example.org
Our President addressed our membership as follows:
It is with deep sadness that I inform you of the death of Isabelle Ingster-Moati, an esteemed member, a dear friend and a special woman.
Isabelle passed away on Saturday January 31 after a brave fight against her illness. We remember her for her smile, her elegance, her dedication to the electrophysiology of the eye, and her passion for teaching our science to young people. Those who knew Isabelle more closely, know that she loved to sing in her work. She would say that song gave serenity to those who had to undergo to our procedures.
Our condolences go to her family and her colleagues. Isabelle will be missed.
Prof A. Patrizia Tormene President ISCEV
2014 – Emiko Adachi awarded “Order of the Sacred Treasure, Gold Rays with Neck Ribbon”
Our distinguished member and founder of the eponymous Award, Prof Emiko Adachi, was awarded “The Order of the Sacred Treasure, Gold Rays with Neck Ribbon”, directly handed to her by the Japanese Emperor. We stand proud and are honoured to have her among us.
2013 – Eberhart Zrenner now “Senior Professor” at University of Tübingen
Eberhart Zrenner, our member, former secratary & president and recipient of the Adachi Award, has received a “Senior Professorship” in Tübingen in April 2013. This means that he can pursue his research and patient care activities in Tübingen Forschungsinstitut für Augenheilkunde” for at least another five years.
It is a particular pleasure to contact you as your new Director of Standards and to thank everyone who completed our survey of ERG practice. We received an impressive 143 responses. As one respondent mentioned, it did take more than 5 minutes to complete, especially for those who took the time to add helpful comments.
The ERG survey was prepared as a co-operative effort with our outgoing Director of Standards, Michael Marmor, Ulrich Kellner and Ruth Hamilton. The data will inform the work of Prof Kellner and his ERG standards committee in preparation of the 2014 update of the ISCEV standard for full-field electroretinography. Below please find a brief synopsis of the survey results. The detailed replies are available as PDF.
If you have suggestions for the update of the ERG standard, please send them to Ulrich Kellner [email@example.com]. The committee will be in touch with ISCEV members for further input when the draft update is available.
Four of the five standard ERG tests are used routinely by >90% of labs
ERG testing is less prevalent for standard oscillatory potentials and recommended dark-adapted strong flash ERGs
Non-standard (weaker or stronger) stimuli are used for some tests
Full-field ERG tests are reported as clinically valuable (routinely or occasionally) as follows
A majority of respondents also record multifocal ERGs and pattern ERGs in their labs. The prevalence of other ERG tests (recorded often or sometimes)
Respondents report a range of calibration methods and frequencies and most, 94%, calibration their systems. Both adults and children are tested 89% of labs. The number of ERGs per year ranges from small units to very large clinical electrophysiology facilities (see figure).
Daphne L McCulloch, ISCEV Director of Standards
2013 – Honorary Doctorate conferred on Eberhart Zrenner, former ISCEV president
We are proud to report that our former President received this→Honorary Doctorate.
In Memoriam – Professor Harold Henkes (1918–2010)
It is with deep sadness we announce that Professor Harold Henkes passed away on September 5 th, 2010 , not long after his wife, who died in December 2009.
Harold Henkes was born in Scheveningen in 1918. He studied medicine for his MD in Utrecht , where he also had his training in ophthalmology. In 1942, he obtained a PhD, based on histological and chemical research on vitamin C.
His continued career took place at the Rotterdam Eye Hospital , where he became Medical Director in 1961. The following year, he was appointed Associate Professor of Ophthalmology and in 1967 Professor of Ophthalmology in Rotterdam , where he was working successfully until his retirement in 1982.
Of his research interests, retinal electrophysiology was the most prominent one. He was one of the founding fathers of the International Society for Clinical Electroretinography (ISCERG), which was established at a meeting organized by Henkes during the International Congress of Ophthalmology in Brussels in 1958. Among others, the Board included Professor Gösta Karpe, Sweden , as President and Dr. Harold Henkes as Secretary General.
Professor Henkes succeeded Professor Karpe as President of ISCERG at the Bad Nauheim Symposium in 1973, a position he held until the Budapest Symposium in 1983, when Professor Sven Erik Nilsson, Sweden , succeeded him. The same year, he was awarded an Honorary Membership of the Society. Under Professor Henkes’ precidency, at the Symposium in Ghent in 1977, the name of the Society was changed into the International Society for Clinical Electrophysiology of Vision (ISCEV) to reflect the broadened field of research of the Society members. Harold Henke’s enthusiastic leadership of ISCEV was greatly appreciated by all members.
Harold Henkes was a Board member of several other Societies, such as the European Ophthalmological Society, where he was first Treasurer and then President. He was a member of Royal Dutch Academy of Science. Furthermore, he was awarded the prestigious ophthalmological von Helmholtz Price. The German Ophthalmological Society made him Honorary Member.
Professor Henkes published a large number of scientific papers in international journals, not only on electroretinography but also on other ophthalmological problems, e.g. on circulatory disturbances of the retina. From 1970 to 1986 he was Editor-in-Chief of Documenta Ophthalmologica, which later became the official journal of ISCEV. Furthermore, he published several important books on the history of ophthalmology.
One of his important interests besides ophthalmology was glass. He created a very large private collection of antique and valuable glass, which he showed to his friends through photos attached to Christmas cards. This collection was finally donated to a museum. He also published books on glass, e.g.”Glass without gloss” in 1994, on utility glass from five centuries, 1300-1800.
In addition to his scientific achievements, Harold Henkes was a wonderful person, always kind and helpful. He was my gentle mentor when I succeeded him as President of ISCEV. His great experience and knowledge were most valuable. We all miss him very much and remember him as a man with a passionate interest in clinical electrophysiology of vision.
I want to thank Professor Van Rij and Dr. Frans Hiddema, Rotterdam , for providing the photograph and valuable information on Professor Henkes’ career.
Sven Erik G. Nilsson, MD, PhD
2010 – Elections
Congratulations to Prof Shuishi Yamamoto, our new vice-president for Asia and Oceania, and to Dr Mineo Kondo who returns for a second term as Board member-at large. Both were elected unopposed by the ISCEV members present at the annual membership meeting on 06 November, 2010 to serve on the ISCEV Board of Directors
THE XLXI ANNUAL ISCEV SYMPOSIUM will be held in Chonqing, China, proposed dates of 13-17 October, 2013.
Daphne McCulloch & David Keating
2010 – The 6th Emiko Adachi Award
The 2010 Emiko Adachi award for long and meritorious service to ISCEV was announced at the XLVIII Symposium Banquet: Congratulations and thank you to Prof Geoffrey Arden winner of the 2010 Emiko Adachi Award for contributions to science and for years of dedicated service to our Society. We look forward to the Award Lecture next year at our Symposium in Québec, Canada.
The 2010 DODT Award
The 2010 Eberhard Dodt Memorial Award for an outstanding presentation at the ISCEV Symposium by a young scientist was awarded to X Y George Kong of Melborne, Australia for his presentation, “Mitochondrial impairment results in increased susceptibility to injury in retinal neurons”. The Awards Committee also commended Alison Foulis (Glasgow, Scotland) and Shiying Li (Chongqing, China)
2010 – Graham Holder: Alcon Award
Professor Graham Holder recieved the prestigous Alcon Award at the ARVO meeting in 2010. A Scientific Selection Committee awards this prize to a small number of outstanding contributors to ophthalmic research throughout the world and honors them both in a symposium that elite members of the eye research community attend (in this case, ARVO) and with an unrestricted research grant. Congratulations to Professor Holder.
2010 – Anne Fulton honoured at Harvard
I am pleased to report that Dr. Anne Fulton has been promoted to Professor of Ophthalmology at Harvard Medical School. This is a well-deserved and hard-earned recognition of Dr. Fulton's continuing contributions to research, teaching, and clinical care.
In the entire history of the Longwood medical area teaching hospitals, there have only been 3 full professors of ophthalmology (Drs. Lois Smith, Elizabeth Engle, and Robert D'Amato.) Dr. Fulton's work in understanding retinal physiology in children is unparalleled in the world, and the level of clinical expertise she and her team offer her patients is equally peerless. Congratulations Dr. Fulton!
David G. Hunter, MD, PhD
In Memoriam – Matthew L Severns (1953–2010)
We have lost another friend – Matthew L. Severns who died shortly after surgery on April 13th 2010. As both a scientist and as a representative of specialist manufacturing, he was an invaluable member of ISCEV working parties and committees and left a legacy of science, innovation and education to the field of clinical electrophysiology of vision. His close colleague and friend, Mary Johnson has prepared the attached obituary and Jonathan S Lyon M.D., has given this tribute to his wonderful character:
For me Matt was my scientific and statistical guide, collaborator, verifier, and encourager. When I had an intuition about proposing a method or solving a problem, I would turn to him to seek either confirmation or a very gentle rebuttal, usually after an elegant and exacting interpretation of the data. Matt expressed an excitement and enthusiasm about data: to see what it had to offer, to make sense of it, and to do this with integrity and honesty. That's the way he approached everything with optimism and caring.
Matt, we will miss you.
Our thoughts are with his wife, Amy Lindsey and the three children.
Michael Bach, President of ISCEV
Obituary: Matthew L Severns PDF
Our dear colleague and role-model, Prof William Woodson Dawson died on March 11th, 2010 after a valient fight with disease, lovingly supported by Judyth. Bill's dedication to ISCEV throughout his 39 years of membership was truly overwhelming. As a superb scientist he was always ready to support, mentor and contribute. And more: he organized two International ISCEV symposia, invented the “DTL” electrode, served on the ISCEV Board of Directors and was recognized by the Emiko Adachi Award for outstanding service and elected as an Honorary Member of ISCEV.
I am proud that I could call him an admired personal friend. I will sadly miss him but also gladly will always remember him.
Michael Bach, President of ISCEV
The University of Florida has a tribute to Dr William Dawson.
Obituary: Dr William Woodson Dawson PDF
|Member-at-Large||Dr Mineo Kondo (Nagoya, Japan)|
|Member-at-Large||Dr Carol Westall (Toronto, Canada)|
THE XLVII ANNUAL ISCEV SYMPOSIUM will be held in Padova, Italy, proposed dates of 5-9 July, 2009 hosted by Dr A Patrizia Tormene.
Congratulations to our new officers and thank you to all of the candidates who offered to work for the benefit of our society.
Daphne McCulloch & David Keating
Electroretinography: The FDA's Viewpoint by Wiley A Chambers Download Powerpoint presentation
This year we have three ISCEV Board positions open for election or re-election. In addition, all members can nominate a candidate for the Emiko Adachi Award for outstanding service to ISCEV.
For the Emiko Adachi Award simply send me the name of your nominee by e-mail (or by any other means). The final selection for this award will be by the Adachi Award committee.
Please consider and nominate suitable candidates for the ISCEV board:
Vice President for Asia and Oceania (Dr. Atsuchi Mizota has served one four-year term and he is eligible and willing to stand for re-election)
Member-at-Large - no geographical constraint (Dr Vaegan has served one four-year term and he is eligible and willing to stand for re-election)
Member-at-Large - no geographical constraint (Open position vacated by Dr. Graham Holder who was elected Director of Education)
Nominations for the above Board positions should be sent to me by an ISCEV member as the nominator. Please mention another member to second the nomination and also confirm the consent of the person nominated that he/she will stand for election.
At the membership meeting in Fontevraud on 15 June, we will reduce the list
of nominees to two for position The final selection will be by a postal
vote of all members.
Finally, in 2006 we will select the location for the XLVII ISCEV Symposium in 2009. We have two generous invitations: from Padova, Italy (Dr A Patrizia Tormene) and from Slovenia (Prof Marko Hawlina and Dr Jelka Brecelj). Please let me know if you are considering inviting ISCEV for a future symposium.
IT IS MY PLEASURE TO ANNOUNCE THE RESULTS OF THE 2005 ISCEV ELECTIONS:
Two new members of the ISCEV Board of Officers from January 2006 ARE:
Prof Laura Frishman; Editor-in-Chief, Documenta Ophthalmologica Prof Marko Hawlina; Board Member-at-Large
THE XLVI ANNUAL ISCEV SYMPOSIUM will be held in Morgantown, West Virginia, USA 11-16 July, 2008 hosted by our out going Editor-in-Chief, Prof J Vernon Odom.
Congratulations to our new officers and thank you to all of the candidates who offered to work for the benefit of our society.
On November 4th and 5th, 2005, a very successful symposium on the Function and Dysfunction of Vision was held in Tübingen in honour of Professor Zrenner's 60th Birthday. Many ISCEV members were among the delegates including four former and current ISCEV Presidents, three Secretaries-General and three former Treasurers. Remarkably, in Prof Zrenner's busy career, he has held all of the above ISCEV Board positions! Our four presidents (Prof SE Nilson, Prof E Zrenner, Prof Y Miyake and Prof M Bach) are shown in this unique picture which was taken by Prof C Barber.
The first award for long and meritorious service to ISCEV was announced at the XLIII Symposium Banquet: Congratulations and thank you to Professor Colin Barber. This is truly a fitting honour for our longest-standing Secretary-General who has done so much to shape the substance and character of ISCEV. We look forward to the first Emiko Adachi Award Lecture at the XLIV Symposium in Fontevraud, France, June 2006.
Daphne McCulloch & David Keating
In this 10th year, Mrs. Elke Dodt, supporter and widow of Prof. Dodt, was in attendance to present the 2005 Eberhard Dodt Award to an outstanding young scientist at the ISCEV Symposium.
Dr Ruth Hamilton of Glasgow who presented her paper based on her recently completed PhD research “The electroretinogram in preterm infants”.
On the strength of the scientific presentations, the Awards Panel selected two highly commendedyoung scientists, Dr. Gil Ben-Shlomo for his presentation, “COP-1 treatment preserves inner retinal function, evidenced by pattern electroretinography, in the rat ocular hypertension model” and Dr. Pedro Gonzalez, for his presentation “The assessment of neuro-retinal toxicity in patients with epilepsy on Vigabtrin”.
Congratulations, to our honoured young scientists.
Daphne McCulloch & David Keating
August 2005: finalised at the 2005 membership meeting in Glasgow. The votes were counted, checked and verified by another Board member, as required by the Bye-Laws. The results are as follows:
|Treasurer||Prof Ulrich Kellner (Berlin) elected for his second term|
|Director of Education||Dr Graham E Holder (London) held this post as member at large|
Congratulations to our returning ISCEV Board Officers !
Daphne McCulloch & David Keating
After his retirement as Professor of Ophthalmology at Nagoya University, former ISCEV president Yozo Miyake was promoted to the Director of National Institute of Sensory Organs in Japan this year. Prof. Myiake's great contributions to our society for more than twenty years are well known to ISCEV members. A major success resulting from ingenious use of the focal ERG has lead to a number of relevant insights into retinal diseases. We are very proud of his promotion to the highest position in Japanese Ophthalmologic Society, and express our sincerest congratulations.
Dr Mineo Kondo & Prof Michael Bach
Elections for the following positions are due in 2005. Preliminary elections took place at the membership meeting on 27 August during the LXIII ISCEV Symposium in Glasgow. (Postal vote for final selections will follow).
Editor of Documenta Ophthalmologica (Prof. Odom has served 2 terms and is not eligible for re-election)
Director of Education new board position (Dr. Graham Holder, Director of Education, will complete two terms as member-at-large at the end of 2005 )
Member at Large no geographical constraint (vacated by Dr. Mitch Brigell who was elected Director of Standards)
Treasurer (Prof. Kellner has served one term and is eligible for a second term)
To nominate someone, write to the Secretary-General specifying the Board Position, the name of the proposed candidate, the name of a seconder for the nomination and the signed consent of the candidate. Candidates letters may be sent separately. They should state that they are willing to stand for the position and, if elected, they are willing to fulfil the duties of the office.
Daphne McCulloch & David Keating
November 2004: The full results of the latest ISCEV elections that took place in Puerto Rico are shown below. The votes were counted, checked and verified by another Board member, as required by the Bye-Laws. The results are as follows:
|Secretary General||Prof Daphne McCulloch (Glasgow)|
|Vice-president (Europe and Africa)||Prof Colin Barber (Nottingham)|
|Director of International Communications||Dr David Keating (Glasgow)|
|Director of Standards||Dr Mitch Brigell (Ann Arbor)|
|Member-at-Large||Prof Masayuki Horiguchi (Toyoake City)|
|Member-at-Large||Prof Pierre Lachapelle (Montreal)|
Thank you for your participation.
Colin Barber & David Keating
The award, in the value of $3000, is provided through a generous endowment from Emiko Adachi upon retirement from her position as Professor and Chair of the Department of Ophthalmology at Chiba University, Japan. Hers was a long and glorious career with many honours, culminating in official recognition from the Japanese government. Despite all of this, she remained extraordinarily proud of her long membership of ISCEV, and her outstanding record of sevice to our society. The award is given annually to someone who, to some degree, has matched this record of service to ISCEV.
Nomination deadline is extended to Friday 6th May , 2005. Full details of the nomination process is available here as a pdf document.
David Keating & Daphne McCulloch
The winner of the 2004 Dodt Award was Dr Chi Luu. Professor Eberhart Zrenner , President of the Society for the Advancement of Neuro-ophthalmological Sciences, which administers the award on behalf of ISCEV presented the prize.
Dr Luu presented a most interesting poster describing a study which has contributed to the understanding of myopia on the one hand and the action of myopia on the electroretinogram on the other. The full text of Professer Zrenner's speech will be in the Newsletter. Unfortunately Frau Dodt was not able to be present at the award ceremony, but she sent a letter via Prof Zrenner which is reproduced in ISCEV News Extra.
Congratulations to Dr Chi Luu.
Colin Barber & David Keating
February 2004: The results of the latest ISCEV elections have been counted and have been checked and verified by another Board member (Prof. Yozo Miyake), as required by the Bye-laws. The results are as follows:
Thank you for your participation!
Colin Barber & Michael Bach
Prof. Emiko Adachi-Usami received the “Medal with Purple Ribbon” from the Japanese goverment. She received this award on account of her tremendous contributions to Retinitis Pigmentosa Society as well as her electrophysiological works in ophthalmology.
Our warmest felicitations, Dr. Adachi-Usami!
The Royal Society, the UK national academy of science, has elected our colleague John Robson as Fellow. John Robson has contributed with many sophisticated investigations to our society. He is also a most knowledgeable co-author of the new calibration guidelines which will appear shortly in Documenta Ophthalmologica (2003, volume 107, issue 1). We are proud to have him as ISCEV member and feel that this is prestigious award is well deserved.
On Saturday, 22 November 2002, Eberhart Zrenner was awarded the “Bundesverdienstkreuz am Bande”, the “Order of Merit” of the Federal Republic of Germany. He was honoured for his long-standing commitment to research in the field of Retinal Degenerations and for his efforts as chairman of Pro Retina’s scientific committee on behalf of the patient self-help organization “Pro Retina Deutschland”.
The medal was conferred by Regierungspräsident Hubert Wicker in lieu of President Johannes Rau during a festive ceremony commemorating the 25th anniversary of the founding of the German Retinitis Pigmentosa Association.
Eberhart Zrenner has been an active member of ISCEV for many years and successfully served as president. We are very proud of him!
Since Peter Butler took over the management of our Journal at Kluwer, many aspects are improving:
Colin Barber & Michael Bach
April 2002: The results of the latest ISCEV elections have been counted and have been checked and verified by another Board member, as required by the Bye-laws. The results are as follows:
Thank you for your participation!
Colin Barber & Michael Bach
You will recall that one of the topic of this year's ISCEV Symposium was: “The rise and fall of vision: from pediatric to geriatric electrophysiology”. Following the Symposium, the Editorial Board of Documenta Ophthalmologica (our Journal) has agreed to a special issue that would include significant papers on these topics.
Those interested in contributing (human or animal studies) to this special issue of Documenta must take the following deadlines into consideration:
Statement of intent to submit: January 1, 2002
Receipt of final manuscript: April 1, 2002
We would appreciate if you consider submitting a manuscript to this special issue following the detailed instructions of Documenta Ophthalmologica. The paper would then, of course, be peer-reviewed.
If you have any questions regarding this matter, please contact either of us at your earliest convenience.
A special issue of Documenta Ophthalmologica is planned that will be dedicated to the topic of 'Genetic Diseases and Animal Models'. As you may remember, this was a major theme of the ISCEV meeting held recently in Orford, Quebec. We hope that ISCEV members will consider submitting a manuscript to this special issue. If so, please bear in mind the following deadlines:
Statement of intent to submit -- January 1, 2002
Receipt of final manuscript -- April 1, 2002
If you have any questions regarding this matter, please contact either of us at your earliest convenience.
Thursday, January 11, 2001
Paul A. Sieving MD PhD, Named Director, National Eye Institute
Ruth L. Kirschstein, M.D., acting director of the National Institutes of Health (NIH), today announced the appointment of Paul A. Sieving, M.D., Ph.D., as director of the National Eye Institute (NEI). Dr. Sieving is currently the Paul R. Lichter Professor of Ophthalmic Genetics and director, Center for Retinal and Macular Degeneration, at the Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor. He will join the NEI in late spring.
Paul has been a very active member of ISCEV for many years. We are very proud of him and wish him a happy & successful office there.
CEVnet – The ISCEV discussion list (CEVnet@mssm.edu)
Some details on list policy
Our intention is to provide an e-mail forum for informal discussions of interesting or perplexing cases, technical issues, economics, and any other matters of interest to the membership. Many of our members are already in the habit of sending an occasional e-mail query to knowledgeable colleagues; the list-sever should greatly facilitate these exchanges, and broaden the international pool of expertise on which we all may call.
The operation of the list is modeled after the very successful “Ped-Ophth” list-server, operated under the auspices of the American Association for Pediatric Ophthalmology and Strabismus (“AAPOS”) for the last decade. In our experience, activity on CEVnet is mostly quite light, and participants should not fear being overwhelmed by messages. Our list-server, graciously provided through the Mount Sinai School of Medicine at no cost, has been very effective in blocking “spam.”
CEVnet participants may unsubscribe at any time by sending an e-note to Scott Brodie, the list moderator, at firstname.lastname@example.org requesting that your e-mail address be removed from the list. If you change your mind, just use the same address to request that you be re-instated.
CEVnet is “closed” list – messages are accepted only from the e-mail addresses on the server's master list. If you change your email address, please let me know by personal email to Scott.Brodie@nyumc.org. There is no objection to a user maintaining more than one active e-mail address, but in that case, all messages will be sent to all active addresses.
In order to post a message to the list, simply send it by e-mail to CEVnet@mssm.edu. Your message will promptly be relayed to everyone on the discussion group mailing list.
The list will operate under the following guidelines:
WAVEFORMS and CLINICAL IMAGES (revised 2020-07-10)
Participants are encouraged to post waveforms and clinical images (fundus photos, fluorescein or ICG angiograms, OCT or fundus autofluorescence images etc.) as part of their discussions or queries. We hope that, over time, the waveforms and images posted on CEVnet will constitute a library of clinical examples available to members for comparison or reference.
A few final suggestions
ISCEV awards travel grants to assist colleagues who would otherwise be unable to attend the ISCEV International Symposium and/or course. If possible, an equal number of travel grants will be awarded to applicants from the ISCEV region1 of that year’s Symposium and to applicants from the two other ISCEV regions. Recipients also receive one year’s free membership to ISCEV and a reduced registration fee offered by the local organizers.